Details for gene set INOH_NEGATIVE FEEDBACK REGULATION OF JAK STAT PATHWAY BY (JAK DEGRADATION SIGNALING)[GSEA]

Table: GSEA Results Summary

Dataset	set04_transDMproB_versus_LMproB
Phenotype	NoPhenotypeAvailable
Upregulated in class	na_pos
GeneSet	INOH_NEGATIVE FEEDBACK REGULATION OF JAK STAT PATHWAY BY (JAK DEGRADATION SIGNALING)
Enrichment Score (ES)	0.5257224
Normalized Enrichment Score (NES)	1.7507797
Nominal p-value	0.0020449897
FDR q-value	0.102926396
FWER p-Value	0.911

Table: GSEA details [plain text format]
	PROBE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	PSMB1	271	3.438	0.0643	Yes
2	PSMB6	406	3.058	0.1272	Yes
3	PSMB10	554	2.796	0.1835	Yes
4	PSMB9	1005	2.291	0.2118	Yes
5	STAT1	1094	2.226	0.2582	Yes
6	PSMB2	1796	1.824	0.2623	Yes
7	JAK3	2010	1.719	0.2903	Yes
8	STAT5A	2045	1.709	0.3276	Yes
9	PSMB3	2090	1.688	0.3640	Yes
10	PSMA5	2104	1.682	0.4019	Yes
11	STAT5B	2139	1.667	0.4383	Yes
12	PSMB8	2176	1.657	0.4744	Yes
13	STAT4	2448	1.564	0.4957	Yes
14	PSMA3	2575	1.524	0.5239	Yes
15	PSMA4	3845	1.130	0.4815	Yes
16	PSMB5	3966	1.100	0.5003	Yes
17	PSMA6	4276	1.032	0.5074	Yes
18	JAK1	4567	0.965	0.5139	Yes
19	PSMD2	4743	0.926	0.5257	Yes
20	PSMA2	6367	0.596	0.4521	No
21	PSMB4	7842	0.322	0.3802	No
22	STAT3	8430	0.220	0.3537	No
23	PSMA7	9241	0.077	0.3118	No
24	PSMB7	9486	0.035	0.2995	No
25	SOCS1	13441	-0.733	0.1036	No
26	PSMA1	14534	-1.013	0.0681	No
27	STAT2	14544	-1.016	0.0909	No
28	PSMC1	15017	-1.140	0.0917	No
29	JAK2	17040	-1.988	0.0285	No
30	TYK2	17565	-2.451	0.0565	No

Fig 2: INOH_NEGATIVE FEEDBACK REGULATION OF JAK STAT PATHWAY BY (JAK DEGRADATION SIGNALING): Random ES distribution
Gene set null distribution of ES for INOH_NEGATIVE FEEDBACK REGULATION OF JAK STAT PATHWAY BY (JAK DEGRADATION SIGNALING)